Curcumin sensitizes response to cytarabine in acute myeloid leukemia by regulating intestinal microbiota.

ABSTRACT:

Purpose

To address whether Curcumin has synergistic effect with cytarabine (Ara-C) in treating acute myeloid leukemia (AML).

Methods

A xenograft AML mouse model was established by injecting HL-60 cells into tail vein of mice to assess the function of Curcumin. Mononuclear cells (MNCs) isolated from AML mice and AML cell lines were used to examine the effect of Curcumin. Metagenomics and metabolomics were used to evaluate the alteration of intestinal microbiota and the change of metabolites in MNCs.

Results

Curcumin treatment sensitized response to Ara-C in MNCs of AML mice, but had no direct effect on AML cell lines. Metagenomics revealed an alteration of intestinal microbiota with Curcumin treatment, which contributes to sensitized response to Ara-C. Curcumin treatme

SUBMITTER: Liu J 

PROVIDER: S-EPMC8807457 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature