Transcriptional Control of Hypoxic Hyphal Growth in the Fungal Pathogen Candida albicans.

ABSTRACT: The ability of Candida albicans, an important human fungal pathogen, to develop filamentous forms is a crucial determinant for host invasion and virulence. While hypoxia is one of the predominant host cues that promote C. albicans filamentous growth, the regulatory circuits that link oxygen availability to filamentation remain poorly characterized. We have undertaken a genetic screen and identified the two transcription factors Ahr1 and Tye7 as central regulators of the hypoxic filamentation. Both ahr1 and tye7 mutants exhibited a hyperfilamentous phenotype specifically under an oxygen-depleted environment suggesting that these transcription factors act as negative regulators of hypoxic filamentation. By combining microarray and ChIP-chip analyses, we have chara

SUBMITTER: Henry M 

PROVIDER: S-EPMC8807691 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature