Review of gene therapies for age-related macular degeneration.

ABSTRACT: Gene therapies aim to deliver a therapeutic payload to specified tissues with underlying protein deficiency. Since the 1990s, gene therapies have been explored as potential treatments for chronic conditions requiring lifetime care and medical management. Ocular gene therapies target a range of ocular disorders, but retinal diseases are of particular importance due to the prevalence of retinal disease and the current treatment burden of such diseases on affected patients, as well as the challenge of properly delivering these therapies to the target tissue. The purpose of this review is to provide an update on the most current data available for five different retinal gene therapies currently undergoing clinical trials for use against age-related macular degeneration (AMD) and the developmen

SUBMITTER: Khanani AM 

PROVIDER: S-EPMC8807824 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature