Malaria abrogates O'nyong-nyong virus pathologies by restricting virus infection in nonimmune cells.

ABSTRACT: O'nyongnyong virus (ONNV) is a re-emerging alphavirus previously known to be transmitted by main malaria vectors, thus suggesting the possibility of coinfections with arboviruses in co-endemic areas. However, the pathological outcomes of such infections remain unknown. Using murine coinfection models, we demonstrated that a preexisting blood-stage Plasmodium infection suppresses ONNV-induced pathologies. We further showed that suppression of viremia and virus dissemination are dependent on Plasmodium-induced IFNγ and are associated with reduced infection of CD45^- cells at the site of virus inoculation. We further proved that treatment with IFNγ or plasma samples from Plasmodium vivax-infected patients containing IFNγ are able to restrict ONNV infection in hu

SUBMITTER: Torres-Ruesta A 

PROVIDER: S-EPMC8807878 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature