Dose-volume predictors of post-radiation primary hypothyroidism in head and neck cancer: A systematic review.

ABSTRACT:

Background and purpose

This systematic review aims to identify radiation dose-volume predictors of primary hypothyroidism after radiotherapy in patients with head and neck cancer (HNC).

Materials and methods

We performed a systematic literature search of Medline, EMBASE and Web of Science from database inception to July 1, 2021 for articles that discuss radiation dose-volume predictors of post-radiation primary hypothyroidism in patients with HNC. Data on the incidence, clinical risk factors and radiation dose-volume parameters were extracted. A meta-analysis was performed using the random-effects model to estimate the pooled odds ratio (OR) of thyroid volume as a predictor of the risk of post-radiation hypothyroidism, adjusted for thyroid radiation dosimetry.

Results

SUBMITTER: Chow JCH 

PROVIDER: S-EPMC8807951 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature