Intra-articular placebo effect in the treatment of knee osteoarthritis: a survey of the current clinical evidence.

ABSTRACT: Knee osteoarthritis (KOA) is a debilitating disease characterized by chronic pain, stiffness, and decreased mobility. Intra-articular injectable therapies show good clinical efficacy in improving symptoms; however, these therapies and their comparators (intra-articular saline) have been associated with a large underlying placebo effect. We aimed to describe the existing evidence on the challenges, hypotheses, and potential solutions to mitigate the intra-articular placebo effect in clinical trials in KOA. A targeted literature review was conducted by searching Embase, MEDLINE®, and CENTRAL using predefined study selection criteria. All eligible studies identified were extracted for relevant data, and results were narratively summarized. Forty-three studies were included following screening

SUBMITTER: Fazeli MS 

PROVIDER: S-EPMC8808023 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature