Periosteal Flaps Enhance Prefabricated Engineered Bone Reparative Potential.

ABSTRACT: The clinical translation of bone tissue engineering for reconstructing large bone defects has not advanced without hurdles. The in vivo bioreactor (IVB) concept may therefore bridge between bone tissue engineering and reconstructive surgery by employing the patient body for prefabricating new prevascularized tissues. Ideally, IVB should minimize the need for exogenous growth factors/cells. Periosteal tissues are promising for IVB approaches to prefabricate tissue-engineered bone (TEB) flaps. However, the significance of preserving the periosteal vascular supply has not been adequately investigated. This study assessed muscle IVB with and without periosteal/pericranial grafts and flaps for prefabricating TEB flaps to reconstruct mandibular defects in sheep. The sheep (n = 14)

SUBMITTER: Abu-Shahba AG 

PROVIDER: S-EPMC8808084 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature