Loop and thiazide diuretic use and risk of chronic kidney disease progression: a multicentre observational cohort study.

ABSTRACT:

Objectives

To evaluate the association between diuretic use by class with chronic kidney disease (CKD) progression and onset of end-stage renal disease (ESRD).

Design

Retrospective cohort study.

Setting

Large integrated healthcare delivery system in Northern California.

Participants

Adults with an estimated glomerular filtration rate (eGFR) 15-59 min/1.73 m² by the CKD-Epidemiology Collaboration equation with no prior diuretic use.

Main outcome measures

ESRD and a renal composite outcome including eGFR <15 mL/min/1.73 m², 50% reduction in eGFR and/or ESRD.

Results

Among 47 666 eligible adults with eGFR 15-59 min/1.73 m² and no previous receipt of loop or thiazide diuretics, mean age was 71 years, 49% were women and

SUBMITTER: Fitzpatrick JK 

PROVIDER: S-EPMC8808372 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature