Paneth Cell Alertness to Pathogens Maintained by Vitamin D Receptors.

ABSTRACT:

Background and aims

Vitamin D exerts a regulatory role over mucosal immunity via the vitamin D receptor (VDR). Although Paneth cells and their products are known to regulate the commensal and pathogenic microbiota, the role that VDRs in Paneth cells play in these responses is unknown.

Methods

We identified the decreased intestinal VDR significantly correlated with reduction of an inflammatory bowel disease risk gene ATG16L1 and Paneth cell lysozymes in patients with Crohn's disease. We generated Paneth cell-specific VDR knockout (VDR^ΔPC) mice to investigate the molecular mechanisms.

Results

Lysozymes in the Paneth cells were significantly decreased in the VDR^ΔPC mice. Isolated VDR^ΔPC Paneth cells exhibited weakened inhibition of pathog

SUBMITTER: Lu R 

PROVIDER: S-EPMC8808465 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature