In silico design of recombinant multi-epitope vaccine against influenza A virus.

ABSTRACT:

Background

Influenza A virus is one of the leading causes of annual mortality. The emerging of novel escape variants of the influenza A virus is still a considerable challenge in the annual process of vaccine production. The evolution of vaccines ranks among the most critical successes in medicine and has eradicated numerous infectious diseases. Recently, multi-epitope vaccines, which are based on the selection of epitopes, have been increasingly investigated.

Results

This study utilized an immunoinformatic approach to design a recombinant multi-epitope vaccine based on a highly conserved epitope of hemagglutinin, neuraminidase, and membrane matrix proteins with fewer changes or mutate over time. The potential B cells, cytotoxic T lymphocytes (CTL), and CD4 T cell epitopes w

SUBMITTER: Maleki A 

PROVIDER: S-EPMC8808469 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature