Cell-type-specific epigenomic variations associated with BRCA1 mutation in pre-cancer human breast tissues.

ABSTRACT: BRCA1 germline mutation carriers are predisposed to breast cancers. Epigenomic regulations have been known to strongly interact with genetic variations and potentially mediate biochemical cascades involved in tumorigenesis. Due to the cell-type specificity of epigenomic features, profiling of individual cell types is critical for understanding the molecular events in various cellular compartments within complex breast tissue. Here, we produced cell-type-specific profiles of genome-wide histone modifications including H3K27ac and H3K4me3 in basal, luminal progenitor, mature luminal and stromal cells extracted from a small pilot cohort of pre-cancer BRCA1 mutation carriers (BRCA1^mut/+ ) and non-carriers (BRCA1^+/+ ), using a low-input ChIP-seq

SUBMITTER: Hsieh YP 

PROVIDER: S-EPMC8808540 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature