Robo2 Drives Target-Selective Peripheral Nerve Regeneration in Response to Glia-Derived Signals.

ABSTRACT: Peripheral nerves are divided into multiple branches leading to divergent synaptic targets. This poses a remarkable challenge for regenerating axons as they select their original trajectory at nerve branch-points. Despite implications for functional regeneration, the molecular mechanisms underlying target selectivity are not well characterized. Danio Rerio (zebrafish) motor nerves are composed of a ventral and a dorsal branch that diverge at a choice-point, and we have previously shown that regenerating axons faithfully select their original branch and targets. Here we identify robo2 as a key regulator of target-selective regeneration (sex of experimental subjects unknown). We demonstrate that robo2 function in regenerating axons is required and sufficient to drive tar

SUBMITTER: Murphy PL 

PROVIDER: S-EPMC8808733 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature