Administration of Maresin-1 ameliorates the physiopathology of experimental autoimmune encephalomyelitis.

ABSTRACT:

Background

Resolution of inflammation is an active and regulated process that leads to the clearance of cell debris and immune cells from the challenged tissue, facilitating the recovery of homeostasis. This physiological response is coordinated by endogenous bioactive lipids known as specialized pro-resolving mediators (SPMs). When resolution fails, inflammation becomes uncontrolled leading chronic inflammation and tissue damage, as occurs in multiple sclerosis (MS).

Methods

SPMs and the key biosynthetic enzymes involved in SPM production were analysed by metabololipidomics and qPCR in active brain lesions, serum and peripheral blood mononuclear cells (PBMC) of MS patients as well as in the spinal cord of mice with experimental autoimmune encephalomyelitis (EAE). We also te

SUBMITTER: Sanchez-Fernandez A 

PROVIDER: S-EPMC8808957 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature