Elevated proportion of TLR2- and TLR4-expressing Th17-like cells and activated memory B cells was associated with clinical activity of cerebral cavernous malformations.

ABSTRACT:

Background

Recent evidences have suggested the involvement of toll-like receptor (TLR)-4 in the pathogenesis of cerebral cavernous malformations (CCM). Elevated frequency of TLR⁺T-cells has been associated with neurological inflammatory disorders. As T-cells and B-cells are found in CCM lesions, the objective of the present study was to evaluate the cytokine profile of T-cells expressing TLR2 and TLR4, as well as B-cell subsets, in asymptomatic (CCM_Asympt) and symptomatic (CCM_Sympt) patients.

Methods

For our study, the cytokine profile from TLR2⁺ and TLR4⁺ T-cell and B-cell subsets in CCM_Asympt and CCM_Sympt patients was investigated using flow cytometry and ELISA. T-cells were stimulated in vitro wi

SUBMITTER: Castro C 

PROVIDER: S-EPMC8808981 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature