Detection of plasma Aβ seeding activity by a newly developed analyzer for diagnosis of Alzheimer's disease.

ABSTRACT:

Objective

To evaluate the diagnostic value of plasma β-amyloid (Aβ) seeding activity measured using a newly developed instrument to distinguish Alzheimer's disease (AD) from other forms of dementia.

Methods

Seventy-nine AD patients, 64 non-AD dementia (NADD) patients, and 75 cognitively normal (NC) subjects were recruited in the study. To measure the levels of Aβ seeding activity in the plasma samples, we have developed an AD-seeds protein analyzer. We used receiver operating characteristic (ROC) curves to quantify the ability of plasma Aβ seeding activity to distinguish between AD and NADD or NC individuals. Spearman's correlation was used to examine the associations between plasma Aβ seeding activity and global cognitive function or conventional AD biomarkers.

Results</

SUBMITTER: Jia J 

PROVIDER: S-EPMC8808989 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature