Down-regulation of PBK inhibits proliferation of human endometrial stromal cells in thin endometrium.

ABSTRACT:

Background

Thin endometrium (TE) is a challenging clinical issue in the reproductive medicine characterized by inadequate endometrial thickness, poor response to estrogen and no effective treatments currently. At present, the precise pathogenesis of thin endometria remains to be elucidated. We aimed to explore the related molecular mechanism of TE by comparing the transcriptome profiles of late-proliferative phase endometria between TE and matched controls.

Methods

We performed a bulk RNA-Seq (RNA-sequencing) of endometrial tissues in the late-proliferative phase in 7 TE and 7 matched controls for the first time. Differential gene expression analysis, gene ontology enrichment analysis and protein-protein interactions (PPIs) network analysis were performed. Immunohistochemist

SUBMITTER: Zhu Q 

PROVIDER: S-EPMC8809007 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature