Systematic review of Mendelian randomization studies on risk of cancer.

ABSTRACT:

Background

We aimed to map and describe the current state of Mendelian randomization (MR) literature on cancer risk and to identify associations supported by robust evidence.

Methods

We searched PubMed and Scopus up to 06/10/2020 for MR studies investigating the association of any genetically predicted risk factor with cancer risk. We categorized the reported associations based on a priori designed levels of evidence supporting a causal association into four categories, namely robust, probable, suggestive, and insufficient, based on the significance and concordance of the main MR analysis results and at least one of the MR-Egger, weighed median, MRPRESSO, and multivariable MR analyses. Associations not presenting any of the aforementioned sensitivity analyses were not graded

SUBMITTER: Markozannes G 

PROVIDER: S-EPMC8809022 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature