Ontology highlight
ABSTRACT:
SUBMITTER: Wheeler DS
PROVIDER: S-EPMC8809084 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Wheeler David S DS Misumi Keizo K Walker Natalie M NM Vittal Ragini R Combs Michael P MP Aoki Yoshiro Y Braeuer Russell R RR Lama Vibha N VN
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20210104 7
Histopathologic examination of lungs afflicted by chronic lung allograft dysfunction (CLAD) consistently shows both mononuclear cell (MNC) inflammation and mesenchymal cell (MC) fibroproliferation. We hypothesize that interleukin 6 (IL-6) trans-signaling may be a critical mediator of MNC-MC crosstalk and necessary for the pathogenesis of CLAD. Bronchoalveolar lavage (BAL) fluid obtained after the diagnosis of CLAD has approximately twofold higher IL-6 and soluble IL-6 receptor (sIL-6R) levels co ...[more]