To Lighten the Burden of Cure: Thyroid Disease in Long-Term Survivors After TBI Conditioning for Paediatric ALL.
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ABSTRACT:
SUBMITTER: Zubarovskaya N
PROVIDER: S-EPMC8809136 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Publications
To Lighten the Burden of Cure: Thyroid Disease in Long-Term Survivors After TBI Conditioning for Paediatric ALL.
Zubarovskaya Natalia N Bauer Dorothea D Ronceray Leila L Poetschger Ulrike U Kurzmann Paulina P Lender Carina C Kuzmina Zoya Z Lawitschka Anita A
Frontiers in pediatrics 20220119
Thyroid disorders are well-studied after allogeneic haematopoietic stem cell transplantation (HSCT) following total body irradiation (TBI)-based conditioning, occurring in 15-30% of paediatric survivors. The toxic effect of TBI is known but data on the role of immunological dysregulation (ID) and chronic graft-versus-host-disease (cGvHD) are scarce. We studied functional and structural thyroid disorders in 97 paediatric ALL patients after TBI-based HSCT, assessing their correlation with patient/ ...[more]
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