Prevalence and patterns of HIV drug resistance in patients with suspected virological failure in North-Western Tanzania.

ABSTRACT:

Background

More than 15 million people in sub-Saharan Africa receive ART. Treatment failure is common, but the role of HIV drug resistance in treatment failure is largely unknown because drug resistance testing is not routinely done. This study determined the prevalence and patterns of HIV drug resistance in patients with suspected virological failure.

Materials and methods

A single high viral load of >1000 viral RNA copies/mL of plasma at any point during ART was considered as suspected virological failure. HIV-1 RNA was extracted from plasma samples of these patients using the QIAamp Viral RNA kit. The protease and part of the RT regions of the HIV pol gene were characterized.

Results

Viral load was determined in 317 patients; 64 (20.2%) had suspected virological fa

SUBMITTER: Henerico S 

PROVIDER: S-EPMC8809186 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature