Clumping Morphology Influences Virulence Uncoupled from Echinocandin Resistance in Candida glabrata.

ABSTRACT: Here, we report two paired sets of an index wild-type Candida glabrata bloodstream isolate and subsequent echinocandin-resistant FKS mutant. One paired set exhibited a higher proportion of clumping cells and was more virulent in the invertebrate host Galleria mellonella than the other paired set. No virulence difference between the paired index and FKS strains was observed. These findings imply a potential link of clumping morphology with virulence in C. glabrata that is uncoupled from FKS-mediated echinocandin resistance. IMPORTANCE Candida glabrata is a leading cause of invasive candidiasis. In contrast to other species, it has a high propensity for developing resistance to echinocandins, which are the first-line treatment. Unlike the dimorphic Candida albicans which can grow inva

SUBMITTER: Hu C 

PROVIDER: S-EPMC8809326 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature