Determinants and Interactions of Oral Bacterial and Fungal Microbiota in Healthy Chinese Adults.

ABSTRACT: Numerous studies have examined the composition of and factors shaping the oral bacterial microbiota in healthy adults; however, similar studies on the less dominant yet ecologically and clinically important fungal microbiota are scarce. In this study, we characterized simultaneously the oral bacterial and fungal microbiomes in a large cohort of systemically healthy Chinese adults by sequencing the bacterial 16S rRNA gene and fungal internal transcribed spacer. We showed that different factors shaped the oral bacterial and fungal microbiomes in healthy adults. Sex and age were associated with the alpha diversity of the healthy oral bacterial microbiome but not that of the fungal microbiome. Age was also a major factor affecting the beta diversity of the oral bacterial microbiome; however, i

SUBMITTER: Cheung MK 

PROVIDER: S-EPMC8809354 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature