Platelet Mitochondrial DNA Methylation as Epigenetic Biomarker of Short-Term Air Pollution Exposure in Healthy Subjects.

ABSTRACT: Air pollution exposure is now considered a growing concern for global public health. RNA or DNA methylation changes caused by air pollution may be related to the development of cardiovascular disease. To investigate the early biomarkers of air pollution exposure, a panel study of eight college students recorded after a business trip from Qingdao to Shijiazhuang and back to Qingdao was performed in this work. The concentration of PM_2.5, PM₁₀, SO₂, NO₂, and CO in Shijiazhuang was higher than that in Qingdao during the study period. The platelet count was positively correlated with air pollutants of 0-6 day moving averages (β_PM2.5 = 88.90; β_PM10 = 61.83; β_SO2 = 41.13; β_NO2 = 57.70; β_CO = 62.99,

SUBMITTER: Sun H 

PROVIDER: S-EPMC8809460 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature