Molecular insights into chirality transfer from double axially chiral phosphoric acid in a synergistic enantioselective intramolecular amination.

ABSTRACT: In the most general practice of asymmetric catalysis, a chiral catalyst, typically bearing a center or an axis of chirality, is employed as the chiral source for imparting enantiocontrol over the developing product. Given the current interest toward optically pure compounds, various forms of chiral induction enabled by diverse chiral sources as well as the use of multiple catalysts under one-pot conditions have been in focus. In one such promising development, an achiral N-sulfonamide protected 1,6-amino allyl alcohol (NaphSO₂NHCH₂C(Ph)₂CH₂CH[double bond, length as m-dash]CHCH₂OH) was subjected to Tsuji-Trost activation and an intramolecular amination to form important chiral pyrrolidine frameworks. A dual catalytic system compr

SUBMITTER: Tribedi S 

PROVIDER: S-EPMC8809490 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature