Expression of lncRNAs NEAT1 and lnc-DC in Serum From Patients With Behcet's Disease Can Be Used as Predictors of Disease.

ABSTRACT: Background: Behçet's disease (BD) is a chronic autoimmune disease. The early diagnosis of BD is very important to avoid serious and/or fatal complications such as eye damage, severe neurological involvement, and large vessel occlusion. New, sensitive biomarkers would aid in rapid diagnosis, the monitoring of disease activity, and the response to treatment. Methods: This study's aim is to identify two immune system-related BD biomarkers. We measured long non-coding RNAs (lncRNAs) NEAT1 (nuclear-enriched abundant transcript 1), and lnc-DC (lncRNA in dendritic cells) in serum by real-time polymerase chain reaction (RT-PCR) in 52 BD patients and 52 controls. We analyzed the association between NEAT1 and lnc-DC and the clinical parameters of BD. Receive

SUBMITTER: Mohammed SR 

PROVIDER: S-EPMC8809491 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature