The present and future of PI3K inhibitors for cancer therapy.
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ABSTRACT:
SUBMITTER: Castel P
PROVIDER: S-EPMC8809509 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Publications
The present and future of PI3K inhibitors for cancer therapy.
Castel Pau P Toska Eneda E Engelman Jeffrey A JA Scaltriti Maurizio M
Nature cancer 20210617 6
Phosphoinositide-3- kinase (PI3K) signaling regulates cellular proliferation, survival and metabolism, and its aberrant activation is one of the most frequent oncogenic events across human cancers. In the last few decades, research focused on the development of PI3K inhibitors, from preclinical tool compounds to the highly specific medicines approved to treat patients with cancer. Herein we discuss current paradigms for PI3K inhibitors in cancer therapy, focusing on clinical data and mechanisms ...[more]
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