Comparing the impact of vaccination strategies on the spread of COVID-19, including a novel household-targeted vaccination strategy.

ABSTRACT: With limited availability of vaccines, an efficient use of the limited supply of vaccines in order to achieve herd immunity will be an important tool to combat the wide-spread prevalence of COVID-19. Here, we compare a selection of strategies for vaccine distribution, including a novel targeted vaccination approach (EHR) that provides a noticeable increase in vaccine impact on disease spread compared to age-prioritized and random selection vaccination schemes. Using high-fidelity individual-based computer simulations with Oslo, Norway as an example, we find that for a community reproductive number in a setting where the base pre-vaccination reproduction number R = 2.1 without population immunity, the EHR method reaches herd immunity at 48% of the population vaccinated with 90% efficiency,

SUBMITTER: Voigt A 

PROVIDER: S-EPMC8809548 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature