Discovering adaptation-capable biological network structures using control-theoretic approaches.

ABSTRACT: Constructing biological networks capable of performing specific biological functionalities has been of sustained interest in synthetic biology. Adaptation is one such ubiquitous functional property, which enables every living organism to sense a change in its surroundings and return to its operating condition prior to the disturbance. In this paper, we present a generic systems theory-driven method for designing adaptive protein networks. First, we translate the necessary qualitative conditions for adaptation to mathematical constraints using the language of systems theory, which we then map back as 'design requirements' for the underlying networks. We go on to prove that a protein network with different input-output nodes (proteins) needs to be at least of third-order in order to provide

SUBMITTER: Bhattacharya P 

PROVIDER: S-EPMC8809615 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature