High temporal resolution measurements of movement reveal novel early-life physiological decline in C. elegans.

ABSTRACT: Age-related physiological changes are most notable and best-studied late in life, while the nature of aging in early- or middle-aged individuals has not been explored as thoroughly. In C. elegans, many studies of movement vs. age generally focus on three distinct phases: sustained, youthful movement; onset of rapidly progressing impairment; and gross immobility. We investigated whether this first period of early-life adult movement is a sustained "healthy" level of high function followed by a discrete "movement catastrophe"-or whether there are early-life changes in movement that precede future physiological declines. To determine how movement varies during early adult life, we followed isolated individuals throughout life with a previously unachieved combination of duration and temporal r

SUBMITTER: Sinha DB 

PROVIDER: S-EPMC8809618 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature