Programmable allosteric DNA regulations for molecular networks and nanomachines.

ABSTRACT: Structure-based molecular regulations have been widely adopted to modulate protein networks in cells and recently developed to control allosteric DNA operations in vitro. However, current examples of programmable allosteric signal transmission through integrated DNA networks are stringently constrained by specific design requirements. Developing a new, more general, and programmable scheme for establishing allosteric DNA networks remains challenging. Here, we developed a general strategy for programmable allosteric DNA regulations that can be finely tuned by varying the dimensions, positions, and number of conformational signals. By programming the allosteric signals, we realized fan-out/fan-in DNA gates and multiple-layer DNA cascading networks, as well as expanding the approach to long-r

SUBMITTER: Zhang C 

PROVIDER: S-EPMC8809682 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature