Effects of Ramelteon on the Prevention of Postoperative Delirium in Older Patients Undergoing Orthopedic Surgery: The RECOVER Randomized Controlled Trial.

ABSTRACT:

Objectives

Postoperative delirium, associated with negative consequences including longer hospital stays and worse cognitive and physical outcomes, is frequently accompanied by sleep-wake disturbance. Our objective was to evaluate the efficacy and short-term safety of ramelteon, a melatonin receptor agonist, for the prevention of postoperative delirium in older patients undergoing orthopedic surgery.

Design

A quadruple-masked randomized placebo-controlled trial (Clinical Trials.gov NCT02324153) conducted from March 2017 to June 2019.

Setting

Tertiary academic medical center.

Participants

Patients aged 65 years or older, undergoing elective primary or revision hip or knee replacement.

Intervention

Ramelteon (8 mg) or placebo MEASUREMENTS: Eighty participa

SUBMITTER: Oh ES 

PROVIDER: S-EPMC8809889 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature