Consensus gene modules related to levels of bone mineral density (BMD) among smokers and nonsmokers.

ABSTRACT: Osteoporosis, as a common metabolic disorder characterized by the decrease of bone mass, can cause fractures, thereby threatening the life quality of females, especially postmenopausal women. Thus, it is necessary to reveal the genes involved in osteoporosis and explore biomarkers for osteoporosis. In this study, two groups, smokers and nonsmokers with different bone mineral density (BMD) levels, were collected from the Gene Expression Omnibus (GEO) database GSE13850. Consensus modules of the two groups were identified; the variety of gene modules between smokers and nonsmokers with different BMD levels was observed; and a consensus module, including 390 genes significantly correlated with different BMD levels, was identified. Function analysis revealed the significantly enriched osteoporo

SUBMITTER: Lin B 

PROVIDER: S-EPMC8810040 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature