Circular RNA expression alteration and bioinformatics analysis in patients with acute cerebral infarction injury.

ABSTRACT: In recent years, a steady increase has been detected in the incidence of acute cerebral infarction (ACI). ACI is caused by blood flow disruption, leading to high disability and mortality rates. Understanding the underlying molecular mechanisms is critical toward developing effective therapeutic approaches. Circular RNAs (circRNAs) are an important class of non-coding RNAs, which have been implicated in several molecular pathways, and their dysregulation has been described in several disease conditions. Here, we set out to explore the possible regulatory role of circRNAs in ischemic stroke and study their molecular function in disease. First, we applied high-throughput sequencing techniques to identify the differential changes of plasma circRNAs expression in patients with acute cerebral in

SUBMITTER: Hu XL 

PROVIDER: S-EPMC8810197 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature