Blood-Based Markers of Neuronal Injury in Adult-Onset Myotonic Dystrophy Type 1.

ABSTRACT:

Introduction

The present study had four aims. First, neuronal injury markers, including neurofilament light (NF-L), total tau, glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase (UCH-L1), were compared between individuals with and without adult-onset myotonic dystrophy type 1 (DM1). Second, the impact of age and CTG repeat on brain injury markers was evaluated. Third, change in brain injury markers across the study period was quantified. Fourth, associations between brain injury markers and cerebral white matter (WM) fractional anisotropy (FA) were identified.

Methods

Yearly assessments, encompassing blood draws and diffusion tensor imaging on a 3T scanner, were conducted on three occasions. Neuronal injury markers were quantified using single molecule

SUBMITTER: van der Plas E 

PROVIDER: S-EPMC8810511 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature