Immunotherapy With Interferon α11, But Not Interferon Beta, Controls Persistent Retroviral Infection.

ABSTRACT: Type I Interferons (IFNs), including numerous IFNα subtypes and IFNβ, are key molecules during innate and adaptive immune responses against viral infections. These cytokines exert various non-redundant biological activities, although binding to the same receptor. Persistent viral infections are often characterized by increased IFN signatures implicating a potential role of type I IFNs in disease pathogenesis. Using the well-established Friend retrovirus (FV) mouse model, we compared the therapeutic efficacy of IFNα11 and IFNβ in acute and chronic retroviral infection. We observed a strong antiviral activity of both IFNs during acute FV infection, whereas only IFNα11 and not IFNβ could also control persistent FV infection. The therapeutic treatment with IFNα11 induced the expression of anti

SUBMITTER: Schwerdtfeger M 

PROVIDER: S-EPMC8810532 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature