Potential application of biomimetic exosomes in cardiovascular disease: focused on ischemic heart disease.

ABSTRACT: Cardiovascular disease, especially ischemic heart disease, is a major cause of mortality worldwide. Cardiac repair is one of the most promising strategies to address advanced cardiovascular diseases. Despite moderate improvement in heart function via stem cell therapy, there is no evidence of significant improvement in mortality and morbidity beyond standard therapy. The most salutary effect of stem cell therapy are attributed to the paracrine effects and the stem cell-derived exosomes are known as a major contributor. Hence, exosomes are emerging as a promising therapeutic agent and potent biomarkers of cardiovascular disease. Furthermore, they play a role as cellular cargo and facilitate intercellular communication. However, the clinical use of exosomes is hindered by the absence of a st

SUBMITTER: Kang IS 

PROVIDER: S-EPMC8810547 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature