Deletion of Six3 in post-proliferative neurons produces weakened SCN circadian output, improved metabolic function, and dwarfism in male mice.

ABSTRACT:

Objective

The increasing prevalence of obesity makes it important to increase the understanding of the maturation and function of the neuronal integrators and regulators of metabolic function.

Methods

Behavioral, molecular, and physiological analyses of transgenic mice with Sine oculis 3 (Six3) deleted in mature neurons using the Synapsin^creallele.

Results

Conditional deletion of the homeodomain transcription factor Six3 in mature neurons causes dwarfism and weakens circadian wheel-running activity rhythms but increases general activity at night, and improves metabolic function, without impacting pubertal onset or fertility in males. The reduced growth in 6-week-old Six3^fl/fl:Synapsin^cre (Six3^syn) males correlates with incre

SUBMITTER: Meadows JD 

PROVIDER: S-EPMC8810556 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature