Light-responsive and Protic Ruthenium Compounds Bearing Bathophenanthroline and Dihydroxybipyridine Ligands Achieve Nanomolar Toxicity towards Breast Cancer Cells.

ABSTRACT: We report new ruthenium complexes bearing the lipophilic bathophenanthroline (BPhen) ligand and dihydroxybipyridine (dhbp) ligands which differ in the placement of the OH groups ([(BPhen)₂ Ru(n,n'-dhbp)]Cl₂ with n = 6 and 4 in 1_A and 2_A , respectively). Full characterization data are reported for 1_A and 2_A and single crystal X-ray diffraction for 1_A . Both 1_A and 2_A are diprotic acids. We have studied 1_A , 1_B , 2_A , and 2_B (B = deprotonated forms) by UV-vis spectroscopy and 1 photodissociates, but 2 is light stable. Luminescence studies reveal that the basic forms have lower energy ³ MLCT states relative to the acidic forms. Complexes 1

SUBMITTER: Oladipupo OE 

PROVIDER: S-EPMC8810589 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature