Neighborhood structural disadvantage and biological aging in a sample of Black middle age and young adults.

ABSTRACT:

Objectives

Research on the social determinants of health has suggested that neighborhood disadvantage may undermine healthy aging and is particularly relevant for understanding health disparities. Recently, this work has examined deoxyribonucleic acid methylation (DNAm)-based measures of biological aging to understand the risk factors for morbidity and mortality. However, it is unknown whether neighborhood disadvantage is related to different indices of DNAm-based aging among Black Americans and whether such neighborhood effects vary as a function of age or gender.

Methods

Our analyses of a Black American sample included 448 young adults and 493 middle-aged adults. We measured neighborhood disadvantage using the Area Deprivation Index at the census block group level. DNAm-ba

SUBMITTER: Lei MK 

PROVIDER: S-EPMC8810597 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature