Diffusion MRI tractography of the locus coeruleus-transentorhinal cortex connections using GO-ESP.

ABSTRACT:

Purpose

The locus coeruleus (LC) is implicated as an early site of protein pathogenesis in Alzheimer's disease (AD). Tau pathology is hypothesized to propagate in a prion-like manner along the LC-transentorhinal cortex (TEC) white matter (WM) pathway, leading to atrophy of the entorhinal cortex and adjacent cortical regions in a progressive and stereotypical manner. However, WM damage along the LC-TEC pathway may be an earlier observable change that can improve detection of preclinical AD.

Theory and methods

Diffusion-weighted MRI (dMRI) allows reconstruction of WM pathways in vivo, offering promising potential to examine this pathway and enhance our understanding of neural mechanisms underlying the preclinical phase of AD. However, standard dMRI analysis tools have generall

SUBMITTER: Solders SK 

PROVIDER: S-EPMC8810611 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature