Automated identification of maximal differential cell populations in flow cytometry data.

ABSTRACT: We introduce a new cell population score called SpecEnr (specific enrichment) and describe a method that discovers robust and accurate candidate biomarkers from flow cytometry data. Our approach identifies a new class of candidate biomarkers we define as driver cell populations, whose abundance is associated with a sample class (e.g., disease), but not as a result of a change in a related population. We show that the driver cell populations we find are also easily interpretable using a lattice-based visualization tool. Our method is implemented in the R package flowGraph, freely available on GitHub (github.com/aya49/flowGraph) and on BioConductor.

SUBMITTER: Yue A 

PROVIDER: S-EPMC8810629 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature