ImmunoPET of trophoblast cell-surface antigen 2 (Trop-2) expression in pancreatic cancer.

ABSTRACT:

Purpose

Without a standard test for pancreatic carcinomas, this highly lethal disease is normally diagnosed at its advanced stage, leading to a low survival rate of patients. Trophoblast cell-surface antigen 2 (Trop-2), a transmembrane glycoprotein, is associated with cell proliferation and highly expressed in most of solid epithelial tumors, including pancreatic cancer. A non-invasive method of imaging Trop-2 would greatly benefit clinical diagnosis and monitoring of pancreatic cancer. In the current study, ⁸⁹Zr-labeled anti-Trop-2 antibody (AF650) was recruited for the systemic evaluation of Trop-2 as an immunoPET target for pancreatic cancer imaging.

Methods

AF650 was conjugated with desferrioxamine (DFO) and then radiolabeled with ⁸⁹Zr. Trop-2 expre

SUBMITTER: Chen W 

PROVIDER: S-EPMC8810666 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature