Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study.

ABSTRACT:

Aims/hypothesis

Type 2 diabetes is a growing global public health challenge. Investigating quantitative traits, including fasting glucose, fasting insulin and HbA_1c, that serve as early markers of type 2 diabetes progression may lead to a deeper understanding of the genetic aetiology of type 2 diabetes development. Previous genome-wide association studies (GWAS) have identified over 500 loci associated with type 2 diabetes, glycaemic traits and insulin-related traits. However, most of these findings were based only on populations of European ancestry. To address this research gap, we examined the genetic basis of fasting glucose, fasting insulin and HbA_1c in participants of the diverse Population Architecture using Genomics and Epidemiology (PAGE) Study.

Me

SUBMITTER: Downie CG 

PROVIDER: S-EPMC8810722 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature