The selective progesterone receptor modulator-promegestone-delays term parturition and prevents systemic inflammation-mediated preterm birth in mice.

ABSTRACT:

Background

Progesterone, acting via its nuclear receptors called progesterone receptors, promotes myometrial relaxation during pregnancy, and suspension of this activity triggers labor. We previously found that 20α-hydroxysteroid dehydrogenase causes a local withdrawal of progesterone in the term and preterm myometrium by converting the progesterone into an inactive form before it accesses the progesterone receptors.

Objective

We hypothesized that a selective progesterone receptor modulator called promegestone, which is not metabolized by 20α-hydroxysteroid dehydrogenase, would sustain progesterone receptor signaling and prevent/delay term labor and preterm labor in mice.

Study design

In the term labor mouse model, promegestone (0.2 mg/dam) or a vehicle were administe

SUBMITTER: Shynlova O 

PROVIDER: S-EPMC8810746 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature