Efficacy and safety of activated prothrombin complex concentrate for the reversal of vitamin K antagonist major bleeding.

ABSTRACT: Data on the use of activated prothrombin complex concentrate (aPCC) for the management of warfarin associated major bleeding is sparse. The objective of the study was to assess the achievement of effective clinical hemostasis using aPCC in patients presenting with major bleeding while on warfarin. We also assessed the safety of the drug. This retrospective study was conducted at a tertiary care teaching center in the USA where patients with major bleeding while receiving warfarin, and received aPCC were included. Efficacy of aPCC in achieving effective hemostasis was assessed according to the International Society of Thrombosis and Hemostasis Scientific and Standardization Subcommittee criteria. Efficacy was also assessed by achieving INR < 1.5 after treatment. The primary safety endpoint

SUBMITTER: Sheikh-Taha M 

PROVIDER: S-EPMC8810750 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature