Cell-free DNA analysis in current cancer clinical trials: a review.

ABSTRACT: Cell-free DNA (cfDNA) analysis represents a promising method for the diagnosis, treatment selection and clinical follow-up of cancer patients. Although its general methodological feasibility and usefulness has been demonstrated, several issues related to standardisation and technical validation must be addressed for its routine clinical application in cancer. In this regard, most cfDNA clinical applications are still limited to clinical trials, proving its value in several settings. In this paper, we review the current clinical trials involving cfDNA/ctDNA analysis and highlight those where it has been useful for patient stratification, treatment follow-up or development of novel approaches for early diagnosis. Our query included clinical trials, including the terms 'cfDNA', 'ctDNA', 'liqu

SUBMITTER: Cisneros-Villanueva M 

PROVIDER: S-EPMC8810765 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature