Transcriptome of human neuroblastoma SH-SY5Y cells in response to 2B protein of enterovirus-A71.

ABSTRACT: Infection with enterovirus-A71 (EV-A71) can cause hand-foot-mouth disease associated with fatal neurological complications. The host response to EV-A71 has not yet been fully elucidated, thus, hampering the development of a precise therapeutic approach. A nonstructural 2B protein of EV-A71 has been reported to involve with calcium dysregulation and apoptosis induction in human neuroblastoma SH-SY5Y cells. However, the molecular mechanism has not been delineated. To address this, comprehensive study of the gene expression from SH-SY5Y cells transfected with EV-A71 2B was carried out by RNA sequencing and transcriptomic analysis. It was found that the signature of the upregulated genes of SH-SY5Y cells expressing EV-A71 2B involved the Ca²⁺-related signaling pathways participating

SUBMITTER: Suanpan K 

PROVIDER: S-EPMC8810792 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature