M6A-related lncRNAs predict prognosis and indicate immune microenvironment in acute myeloid leukemia.

ABSTRACT: Acute myeloid leukemia (AML) is a complex hematologic malignancy. Survival rate of AML patients is low. N6-methyladenosine (m⁶A) and long non-coding RNAs (lncRNAs) play important roles in AML tumorigenesis and progression. However, the relationship between lncRNAs and biological characteristics of AML, as well as how lncRNAs influence the prognosis of AML patients, remain unclear. In this study. In this study, Pearson correlation analysis was used to identify lncRNAs related to m⁶A regulatory genes, namely m⁶A-related lncRNAs. And we analyzed their roles and prognostic values in AML. m⁶A-related lncRNAs associated with patient prognosis were screened using univariate Cox regression analysis, followed by systematic analysis of the relationship bet

SUBMITTER: Zhong F 

PROVIDER: S-EPMC8810799 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature