Dataset Information

Predicting disordered gambling across adolescence and young adulthood from polygenic contributions to Big 5 personality traits in a UK birth cohort.

ABSTRACT:

Background and aims

Previous research has demonstrated phenotypical associations between disordered gambling (DG) and Big 5 personality traits, and a twin study suggested that shared genetic influences accounted for a substantial portion of this relation. The present study examined associations between DG and polygenic scores (PSs) for Big 5 traits to measure the shared genetic underpinnings of Big 5 personality traits and DG.

Design

Zero-inflated negative binomial regression models estimated associations between Big 5 PSs and past-year and life-time assessments of DG in a longitudinally assessed population-based birth cohort.

Setting

United Kingdom.

Participants

A total of 4729 unrelated children of European ancestry from the Avon Longitudinal Study of Parents and Children (ALSPAC) with both phenotypical and genetic data.

Measurements

Phenotypical outcomes included past-year assessment of DG using the problem gambling severity index (PGSI) and life-time assessment of DSM-IV pathological gambling symptoms (DPG) across the ages of 17, 20 and 24 years. Polygenic scores were derived for the Big 5 personality traits of agreeableness, extraversion, conscientiousness, openness and neuroticism using summary statistics from genome-wide association studies (GWAS).

Findings

PSs for agreeableness [β= - 0.25, standard error (SE) = 0.054, P = 3.031e-6, ΔR² = 0.008] and neuroticism (β=0.14, SE = 0.046, P = 0.0017, ΔR² = 0.002) significantly predicted PGSI scores over and above included covariates (i.e. sex and first five ancestral principal components). PSs for agreeableness (β= - 0.20, SE = 0.056, P = 0.00036, ΔR² = 0.003) and neuroticism, when interactions with age were taken into account (β = 0.29, SE = 0.090, P = 0.002, ΔR² = 0.004), also predicted DPG scores.

Conclusions

Polygenic contributions to low agreeableness and high neuroticism appear to predict two measures of disordered gambling (problem gambling severity index and life-time assessment of DSM-IV pathological gambling symptoms). Polygenic scores for neuroticism interact with age to suggest that the positive association becomes stronger from adolescence through young adulthood.

SUBMITTER: Spychala KM

PROVIDER: S-EPMC8810893 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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Publications

Predicting disordered gambling across adolescence and young adulthood from polygenic contributions to Big 5 personality traits in a UK birth cohort.

Spychala Kellyn M KM Gizer Ian R IR Davis Christal N CN Dash Genevieve F GF Piasecki Thomas M TM Slutske Wendy S WS

Addiction (Abingdon, England) 20210908 3

<h4>Background and aims</h4>Previous research has demonstrated phenotypical associations between disordered gambling (DG) and Big 5 personality traits, and a twin study suggested that shared genetic influences accounted for a substantial portion of this relation. The present study examined associations between DG and polygenic scores (PSs) for Big 5 traits to measure the shared genetic underpinnings of Big 5 personality traits and DG.<h4>Design</h4>Zero-inflated negative binomial regression mode ...[more]

PMID: 34342067

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Dataset Information

Predicting disordered gambling across adolescence and young adulthood from polygenic contributions to Big 5 personality traits in a UK birth cohort.

Background and aims

Design

Setting

Participants

Measurements

Findings

Conclusions

Publications

Predicting disordered gambling across adolescence and young adulthood from polygenic contributions to Big 5 personality traits in a UK birth cohort.

Similar Datasets

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