Pharmacologic treatment with OKN-007 reduces alpha-motor neuron loss in spinal cord of aging mice.

ABSTRACT: Aging is associated with molecular and functional declines in multiple physiologic systems. We have previously reported age-related changes in spinal cord that included a decline in α-motor neuron numbers, axonal loss, and demyelination associated with increased inflammation and blood-spinal cord barrier (BSCB) permeability. These changes may influence other pathologies associated with aging, in particular loss of muscle mass and function (sarcopenia), which we and others have shown is accompanied by neuromuscular junction disruption and loss of innervation. Interventions to protect and maintain motor neuron viability and function in aging are currently lacking and could have a significant impact on improving healthspan. Here we tested a promising compound, OKN-007, that has known antioxid

SUBMITTER: Piekarz KM 

PROVIDER: S-EPMC8811061 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature